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Since the resumption of football in Germany, Schalke have lost all four matches without scoring a goal leaving them treading water in mid-table.
Union Berlin meanwhile are similarly out of form, without a win since February and just four points above the relegation play-off place.
A late goal back in November saw Schalke claim a 2-1 victory against the side from the capital and another win for Wagner's men is priced at 2/1 (3.00).
Schalke have midfielder Weston Mckennie suspended, while captain Omar Mascarell looks set to miss out through injury once more along with Banjamin Stambouli, Amine Harit and Suat Serdar.
Union Berlin are without injured duo Sheraldo Becker and Julian Ryerson.
Schalke's awful run of form in 2020 has coincided with their seeming inability to find the back of the net.
The Gelsenkirchen outfit have scored just three goals in their last 11 Bundesliga matches, while on the road they have failed to score in five of their last six games.
Schalke's losing streak must end at some point and they will view their trip to struggling Union Berlin as a great chance to pick up their first points since the restart.
Yet with the team from the Veltins-Arena playing poorly and devoid of confidence they are unlikely to produce a goal-filled performance.
Union Berlin meanwhile will be happy to be out of the relegation spots heading into the last few matches of their debut season in the top flight, and their home form is the reason why they are in a good position to avoid the drop.
Urs Fischer's team boast one of the strongest home defensive record's in the Bundesliga and they should be able to keep things tight once more on Sunday.
In terms of goals per game, Union Berlin's matches average the 15th lowest total while Schalke's games average the 16th lowest in the 18-team Bundesliga.
Opposing a high scoring match therefore makes plenty of sense and under 2.5 goals can be backed at 8/11 (1.72).
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Odds correct at the time of writing. Please gamble responsibly.