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Meetings between these fierce cross-city rivals are usually some of the most raucous and colourful occasions of the season, yet Thursday night's clash will take place behind closed doors making it a uniquely subdued experience.
Nevertheless, both teams will want to hit the ground running with three points as Sevilla aim to consolidate a top-four spot and Betis look to keep alive their outside hopes of claiming a European berth.
Sevilla have won five of the last eight derbies including each of the last two and Julen Lopetegui's side can be backed at 17/20 (1.85) with bet365.
Betis meanwhile have only won once away from home all season, with that victory coming at struggling Mallorca back in November.
The hosts have Serbian midfielder Nemanja Gudelj suspended having picked up a fifth yellow card of the season in the final match before the season was halted.
Top scorer Lucas Ocampos could also be missing with the Argentine forward having missed training this week with a suspected muscle problem.
Betis have practically a fully fit squad with striker Juanmi Jimenez the only likely absentee.
After such an extended period out and during such unprecedented circumstances it is difficult to know what kind of shape both sides are in heading into this clash.
One thing however is clear, the tangible advantage of playing at home has been taken away from Sevilla and the Andalusians are usually a side that thrive in front of their own fans.
This season though their record in their own stadium has been less impressive with Lopetegui's men winning more matches and scoring more goals on the road than at home.
They may sit third in the table, but Sevilla's record of 19 home goals this term is bettered by nine teams in the division and finding the back of the net has been one of the team's biggest problems.
Betis for their part have managed just 11 goals in 13 away matches (only three teams have scored fewer) and given the respective records of the two teams not to mention the circumstances, this derby could be a low-scoring affair.
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Odds correct at the time of writing. Please gamble responsibly.