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Bruno Labbadia has overseen three wins and a draw since taking over during the Bundesliga's hiatus, extending the team's unbeaten run to six matches.
However, they are 6/1 (7.00) outsiders with bet365 to make a massive statement by coming out on top at this ground for the first time since 2013.
The last meeting between this pair at this ground resulted in a 2-2 draw back in October 2018, and there are odds of 17/4 (5.25) available on them cancelling each other out once again.
Mats Hummels is suspended after picking up a fifth yellow card of the campaign, while Mahmoud Dahoud, Marco Reus, Nico Schulz and Dan-Axel Zagadou are all injured and Erling Haaland doubtful.
Santiago Ascacibar remains out with a foot injury, with Matheus Cunha, Marius Wolf, Thomas Kraft and Per Skjelbred all facing late fitness tests.
Die Alte Dame are clearly playing with a renewed sense of confidence at the moment, having scored 16 goals in the last six fixtures - one more than in their previous 16 league matches combined.
Meanwhile, Lucien Favre's men have been in prolific form all campaign after hitting the net 80 times in 29 league games, just two shy of their record for a full Bundesliga campaign.
That kind of form makes odds of 4/5 (1.80) seem like solid value on both teams getting on target in a match that produces at least three goals, particularly as that bet would have paid out in each of the last three meetings between Dortmund and Hertha.
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Odds correct at the time of writing. Please gamble responsibly.