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The Blaugrana enjoyed a 4-0 victory at Mallorca on Saturday night while Leganes suffered a 2-1 home defeat at the hands of fellow strugglers Valladolid.
Barca's last home league defeat came back in November 2018 and the subsequent 26 games have brought 24 wins and two draws.
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Left-back Jordi Alba scored at the weekend but also picked up his fifth yellow card of the season, meaning he is suspended for Tuesday's clash.
ClementLenglet will return from suspension while the likes of Luis Suarez, Ivan Rakitic and Arthur are all likely to come into the starting eleven.
Leganes have two key players suspended, with first-choice centre-back Dimitris Siovas and top scorer Oscar Rodriguez both unavailable.
Leganes have managed to cause Barcelona some problems over the last couple of seasons and back in November, the Catalans had to come from behind to win 2-1 when the sides met in Madrid.
They have also scored in each of their three previous league visits to Camp Nou, although that record looks set to end on Tuesday with Los Pepineros badly struggling in the final third.
Indeed, the team from the Spanish capital are the lowest scorers in the division and just eight of their 22 goals this season have come on the road.
Suspended midfielder Oscar Rodriguez accounts for 36 per centof their total goals and no one in the squad comes close to matching his total of eight strikes.
Leganes have failed to score in seven of their last 11 away games and they are likely to get precious few chances to do so against the league leaders.
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