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Liverpool will be without first-choice goalkeeper Alisson when they face Bournemouth on Saturday and the return leg of a Champions League clash with Atletico Madrid, with Jurgen Klopp revealing that the Brazilian has picked up a hip injury.
Adrian provided cover at Stamford Bridge and will be asked to step in again for a home date with the Cherries.
That is because Klopp has been forced into making a change to this Premier League plans between the sticks.
It is unclear precisely how long Alisson will be sidelined for, but it could be that he is not seen again until after the next international break.
That news represents a major blow to Liverpool as they prepare for the return leg of a meeting with Atletico that they currently trail 1-0 on aggregate, with another big European night being lined up at Anfield.
Klopp told reporters when offering his latest fitness update: "Unfortunately Ali is out.
"He had a little incident in training before the Chelsea game. We all thought it was nothing and it was clear he would not play anyway, the plan was he was on the bench.
"There, we thought, 'Come on, we don't have to take any risks' so left him out of the squad. [There was a] scan the next day and they found something. So now he is out. We will see next week for sure and then we will see."
Klopp added on the nature of the injury: "Muscle, slight, in the hip region. A small muscle. You [the reporters] could all do your work still but a professional goalkeeper is slightly different. That's the situation.
"After the international break is back 100%."
While Liverpool have seen their most reliable last line of defence hand them an unwelcome selection headache, Klopp was able to deliver more positive news elsewhere.
It could be that Henderson comes back into contention for a return date with Atletico, while Naby Keita is also ready for action.
Klopp added: "Naby trained. Jordan has a chance (for Atletico) but not for Bournemouth."
Whoever is available against Bournemouth and Atletico, Klopp is eager to see his side get back on track.
The Premier League title is still very much within reach, but the Merseyside giants are eager to avoiding limping over the line at home and abroad.
"Winning gives you confidence, losing takes it away that is normal," said Klopp.
"One defeat feels like two, not a massive difference, it is just how you get back on track. You can do that by working hard. We have to fight to get back on track. We have to do that as a unit.
"How opponents play against us is not new, it is the same, a defensive block and counters with set pieces.
"Bournemouth are dangerous from them so we have to 100% spot on. We have to play football, force a way through, switch sides, create space and protect it perfectly."